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Febuxostat (Uloric)

Cat No.
CEI-0355
Description
Febuxostat (Uloric)
Alias
Adenuric
CAS No.
144060-53-7
Molecular Weight
316.37
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
Adenuric
Targets
XO
Molecular Formula
C16H16N2O3S
Solubility
No
In vitro
Febuxostat displays potent mixed-type inhibition of the activity of purified bovine milk XO, with Ki and Ki values of 0.6 and 3.1 nM respectively. Febuxostat(TMX-67), a newly synthesized xanthine oxidase/xanthine dehydrogenase (XOD/XDH) inhibitor, has almost no effect on DNFB-sensitized mice. At concentrations up to 100 muM, febuxostat has no significant effects on the activities of the following enzymes of purine and pyrimidine metabolism: guanine deaminase, hypoxanthine-guanine phosphoribosyltransferase, purine nucleoside phosphorylase, orotate phosphoribosyltransferase and orotidine-5-monophosphate decarboxylase.
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