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GANT58
Cat No.
CEI-0520
Description
Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
Alias
NSC75503
Appearance
Off-white solid
Product Overview
A Hedgehog (Hh) signaling pathway inhibitor
CAS No.
64048-12-0
Molecular Weight
341.4
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
NSC75503
Targets
Hh
Molecular Formula
C₂₄H₁₆N₄S
Chemical Name
2,3,4,5-Tetra(4-pyridyl)thiophene
Solubility
DMSO
Shipping Conditions
Gel Pack
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