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GANT61

Cat No.
CEI-0521
Description
Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC50 = 5 µM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice.
Alias
NSC 136476
Appearance
White solid
Product Overview
A Hedgehog (Hh) signaling pathway antagonist
CAS No.
500579-04-4
Molecular Weight
258.23
Purity
>98% by TLC
Storage
-20 centigrade
Synonyms
NSC 136476
Targets
Hh
Molecular Formula
C₂₇H₃₅N₅
Chemical Name
2,​2'-​[[dihydro-​2-​(4-​pyridinyl)-​1,​3(2H,​4H)-​pyrimidinediyl]bis(methylene)]bis(N,​N-​dimethyl-​benzenamine)
Solubility
DMSO (5 mg/ml)
Shipping Conditions
Gel pack
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