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Enzymes for Research, Diagnostic and Industrial Use

GNF-5837

Cat No.
CEI-1156
Description
GNF-5837 is a potent, selective and orally bioavailable pan-TRK inhibitor of TRKA, TRKB and TRKC with the IC50 of 11nM, 9nM and 7nM, respectively.
Abbr
GNF-5837(NTRK1, NTRK2, NTRK3)
Alias
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
CAS No.
1033769-28-6
Molecular Weight
535.49
Purity
> 95%
Storage
4 centigrade
Synonyms
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Targets
TRKA, TRKB, TRKC
IC50
11nM, 9nM, 7nM
Molecular Formula
C28H21F4N5O2
Chemical Name
(Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
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