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Enzymes for Research, Diagnostic and Industrial Use

GSK1059615

Cat No.
CEI-0107
Description
GSK1059615
CAS No.
958852-01-2
Molecular Weight
333.36
Purity
>99%
Storage
2 years at -20 centigrade
Targets
PI3K-alpha
Molecular Formula
C18H11N3O2S
Solubility
No
In vitro
As a novel and dual inhibitor, GSK1059615 can inhibit PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma and mTOR with IC50 of 0.4 nM, 0.6 nM, 2 nM, 5 nM and 12 nM. In T47D and BT474 cancer cells, GSK1059615 inhibits the phosphorylation of Akt at S473, with IC50 of 40 nM.
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