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GSK-J4 hydrochloride

Cat No.
CEI-0547
Description
Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (IC50> 50 µM in vitro. When administered to human primary macrophages, GSK-J4 can reduce lipopolysaccharide (LPS)-induced proinflammatory cytokine production, most notably including that of TNFα (IC50 = 9 µM).
Appearance
Liquid
Product Overview
Histone demethylase JMJD3/UTX inhibitor
CAS No.
1797983-09-5
Molecular Weight
540.54
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
KDM6B
Molecular Formula
C24H27N5O2 . HCL
Chemical Name
Ethyl 3-​((6-​(4,​5-​dihydro-​1H-​benzo[d]azepin-​3(2H)-​yl)-​2-​-(pyridin-2- yl)pyrimidin-4-yl)amino)propanoate, monohydrochloride
Shipping Conditions
Gel pack
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