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GW-441756

Cat No.
CEI-0964
Description
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Blocks TrkA-mediated gammaH2AX production and apoptosis in TrkA-overexpressing cells. Cell permeable.
Abbr
GW-441756(NGFR)
Alias
1, 3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3, 2-b]pyridin-2-one
Appearance
Orange powder
Product Overview
NGFR inhibitor
CAS No.
504433-23-2
Molecular Weight
275.1
Purity
98% (TLC: 5% CH3OH: CH2Cl2; Rf=0.4) mixture of E
Synonyms
1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Targets
NGFR
Molecular Formula
C17H13N3O
Solubility
May be dissolved in DMSO (25 mg/ml); or Ethanol (100 mg/ml)
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