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Galiellalactone

Cat No.
CEI-1604
Description
Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM. The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.
Form
A white lyophilized powder
CAS No.
133613-71-5
Molecular Weight
194.2
Purity
>=95%
Stability
2 years when stored properly
Storage
Store at -20° C
Molecular Formula
C11H14O3
Chemical Name
(7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one
Formulation
In Phosphate buffer saline (pH 7.4) containing 20% glycerol 1mM DTT.
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