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Enzymes for Research, Diagnostic and Industrial Use

I-BET151

Cat No.
CEI-0410
Description
A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays high efficacy against human and murine MLL-fusion leukemic cell lines, through the induction of early cell cycle arrest and apoptosis. The mode of action is, at least in part, due to suppressing the transcription of key genes (BCL2, C-MYC and CDK6) that are critical for MLL-fusion leukemia maintenance.
Alias
GSK1210151A
Appearance
Yellow solid
Product Overview
A BET bromodomain inhibitor
CAS No.
1300031-49-5
Molecular Weight
434.27
Purity
>95% by HPLC
Storage
+4 centigrade
Synonyms
GSK1210151A
Targets
BRD4, BRD3
Molecular Formula
C 23 H 21 N 5 O 3
Solubility
DMSO
Shipping Conditions
RT
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