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ICG-001

Cat No.
CEI-0452
Description
A specific inhibitor of Wnt/β-catenin signaling pathway. It down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein (CBP). ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
Appearance
Off-white solid
Product Overview
A specific inhibitor of Wnt/β-catenin signaling pathway
CAS No.
847591-62-2
Molecular Weight
516.67
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
CREB1
Molecular Formula
C33H32N4O4
Chemical Name
(6S,9aS)-Hexahydro-6-[(4-hydroxyphe­nyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(­phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-c­arboxamide
Solubility
DMSO (>10 mg/ml)
Shipping Conditions
Gel pack
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