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IKK-3 Inhibitor

Cat No.
CEI-1368
Product Overview
An IKK-3 Inhibitor. The NF-κ B/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory Iκ B proteins. NF-κ B is activated upon degradation of Iκ B following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κ B. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.
CAS No.
862812-98-4
Molecular Weight
469.53
Storage
Store at -20°C
Targets
IKK-3
Molecular Formula
C22H19N3O5S2
Chemical Name
5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile
Solubility
DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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