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IOX1

Cat No.
CEI-0549
Description
Cell-permeable. A histone demethylase (HDM) JMJD nhibitor. Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50s = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 µM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling.
Appearance
White solid
Product Overview
Histone demethylase JMJD inhibitor
CAS No.
5852-78-8
Molecular Weight
415.28
Purity
>95% by HPLC
Storage
-20 centigrade
Targets
KDM6B, KDM3A, KDM4A, KDM4E, KDM4C
Molecular Formula
C 10 H 7 NO 3
Chemical Name
8-Hydroxy-5-quinolinecarboxylic acid; 8-Hydroxy-5-quinolinecarboxylic acid
Solubility
H₂O (20 mM) and MeOH (5 mg/ml)
Shipping Conditions
Gel pack
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