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IWP-2

Cat No.
CEI-0595
Description
Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling IC50 = 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion.
Appearance
White to off-white solid
Product Overview
An inhibitor of Wnt secretion and processing
CAS No.
686770-61-6
Molecular Weight
201.25
Purity
>98% by TLC
Storage
-20 centigrade
Targets
PORCN
Molecular Formula
C₂₂H₁₈N₄O₃S₃
Chemical Name
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Solubility
DMSO
Shipping Conditions
Gel pack
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