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IWP-3

Cat No.
CEI-0615
Description
An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC50 = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 µM).
Alias
Inhibitor of Wnt Production-3
Appearance
Off-white solid
Product Overview
An inhibitor of Wnt production
CAS No.
687561-60-0
Molecular Weight
211.22
Purity
>98%
Storage
-20 centigrade
Synonyms
Inhibitor of Wnt Production-3
Targets
phosphatsae
Molecular Formula
C22H17FN4O2S3
Chemical Name
2-​[[3-​(4-​fluorophenyl)-​3,​4,​6,​7-​tetrahydro-​4-​oxothieno[3,​2-​ d]pyrimidin-​2-​yl]thio]-​N-​(6-​methyl-​2-​benzothiazolyl)-​acetamide
Solubility
DMSO (10 mg/ml)
Shipping Conditions
Gel pack
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CAS No.136194-77-9
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