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Itraconazole
Cat No.
CEI-0524
Description
A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that Itraconazole inhibits Hedgehog (Hh) signaling pathway activity (IC50 = 0.8 µM) as well as blocks the VEGFR2 glycosylation, trafficking, and signaling in endothelial cells.
Alias
Oriconazole, R51211, Sporanox
Appearance
Yellow solid
Product Overview
An antifungal agent and Hh signaling inhibitor
CAS No.
84625-61-6
Molecular Weight
489.99
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
Oriconazole, R51211, Sporanox
Targets
Hh
Molecular Formula
C 35 H 38 Cl 2 N 8 O 4
Chemical Name
(2R,4S)-rel-1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
Solubility
DMSO (>20 mg/ml)
Shipping Conditions
Gel pack
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