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JAK2 Inhibitor III, SD-1029

Cat No.
CEI-1062
Description
A cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in cell-free kinase assays at a concentration of 10 µM. Effectively inhibits cell proliferation in JAK-activated BA/F3 cell lines as well as phosphorylation and nuclear translocation of cellular Stat3
Abbr
JAK2 Inhibitor III, SD-1029(JAK2)
Alias
JTK10, THCYT3
CAS No.
118372-34-2
Molecular Weight
639.3
Purity
>80% by HPLC (sum of isomers)
Storage
+2 centigrade to +8 centigrade
Synonyms
JTK10, THCYT3
Targets
JAK2
Molecular Formula
C25H30Cl2N2O3 • 2HBr
Chemical Name
9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione, 2HBr, NSC 371488
Solubility
DMSO
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