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JAK2 Inhibitor II

Cat No.
CEI-1061
Description
A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
Abbr
JAK2 Inhibitor II(JAK2)
Alias
JTK10, THCYT3
CAS No.
1837-91-8
Molecular Weight
557.5
Purity
> 97% by GC
Storage
+2 centigrade to +8 centigrade
Synonyms
JTK10, THCYT3
Targets
JAK2
Molecular Formula
C6H6Br6
Chemical Name
1,2,3,4,5,6-Hexabromocyclohexane
Solubility
DMSO
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