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JNJ-38877605

Cat No.
CEI-0039
Description
JNJ-38877605 is a small-molecule, ATP-competitive inhibitor of the catalytic activity of c-Met.
CAS No.
943540-75-8
Molecular Weight
377.35
Purity
>99%
Storage
2 years at -20 centigrade
Targets
c-Met
Molecular Formula
C19H13F2N7
Chemical Name
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Solubility
DSMO 15 mg/mL Water
In vitro
JNJ-38877605 is a small-molecule, ATP-competitive inhibitor of the catalytic activity of c-Met. JNJ-38877605 showed around 600-fold selectivity for c-Met compared with a panel of 250 diverse tyrosine and serine-threonine kinases and was found to potently inhibit HGF-stimulated and constitutively activated c-Met phosphorylation in vitro.
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