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LDN-57444

Cat No.
CEI-0691
Description
Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 µM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.
Appearance
Brown to dark brown solid
Product Overview
A selective UCHL1 inhibitor
CAS No.
668467-91-2
Molecular Weight
992.79
Purity
Dye content: ~ 80%
Storage
-20 centigrade
Targets
UCHL1
Molecular Formula
C 17 H 11 Cl 3 N 2 O 3
Chemical Name
3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444
Solubility
H 2 O (10 mg/ml)
Shipping Conditions
Gel pack
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