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LTA4 (Leukotriene A4 methyl ester)

Cat No.
CSUB-0864
Description
LTA4 (Leukotriene A4 methyl ester) is a member of the leukotriene family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes possess a conjugated triene structure which gives them their name. They are generally isolated from leukocytes and primarily act through specific G protein-coupled receptors. Leukotriene A4 methyl ester is an unstable intermediate in the biosynthesis of LTB4 and LTC4. Observations show that the naturally occuring free acid is a substrate for LTA4H (LTA4 hydrolase) and LTC4 synthase and plays a central role in transcellular leukotriene and lipoxin biosynthesis. It has also been shown to mobilize Ca2+ in human neutrophils. This product is supplied as the methyl ester for higher stability.
Applications
An unstable intermediate in the biosynthesis of LTB4 and LTC4
Form
Liquid
CAS No.
73466-12-3
Molecular Weight
332.5
Purity
>95%
Storage
Store at -80° C
Synonyms
(-)-LEUKOTRIENE A4 METHYL ESTER; LEUKOTRIENE A4 METHYL ESTER; 5S-TRANS-5,6-OXIDO-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID, METHYL ESTER; (-)-leukotriene A4; LEUKOTRIENE A4-METHYLESTER SOLUTION (100UG/ML HEXANE/1% TRIETHYLAMINE)
Molecular Formula
C21H32O3
MDL Number
MFCD00065847
Melting Point
28-32° C (lit.)
Solubility
Soluble in chloroform.
Substrates
PKA
Refractive Index
1.65 (Predicted)
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