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Enzymes for Research, Diagnostic and Industrial Use

LY2784544

Cat No.
CEI-0190
Description
LY2784544
CAS No.
1229236-86-5
Molecular Weight
469.94
Purity
>99%
Storage
2 years at -20 centigrade
Targets
JAK2 V617F
Molecular Formula
C23H25ClFN7O
Solubility
No
In vitro
LY2784544 potently inhibited the JAK2 V617F-STAT5 signaling with IC50 of 55 nM, but the IC50 for inhibiting wild type JAK2 is 2.26 uM. LY2784544 selectively inhibit the JAK2 V617F-driven cell proliferation with IC50 of 68 nM.In Ba/F3 cell model, LY2784544 can inhibit JAK2 V617F signaling and induce apoptosis with EC50 of 113 nM.
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