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Enzymes for Research, Diagnostic and Industrial Use

LYS6K2

Cat No.
CEI-0967
Description
A selective inhibitor of the p70 ribosomal S6 kinase (S6K). Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 uM with no activity at GSK3beta and Erk1/2 at 10 uM. Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K. Cell permeable.
Abbr
LYS6K2(RPS6KB1)
Alias
4-(4-(4-(4-fluoro-3-(trifluoromethyl) phenyl)-1-methyl-1H-imidazol-2-yl) piperidin-1-yl)-1H-pyrazolo [3, 4-d] pyrimidine
Appearance
Yellow solid
Product Overview
S6K Inhibitor
CAS No.
1082949-67-4
Molecular Weight
445.4
Purity
>97% (HPLC); NMR (Conforms)
Synonyms
4-(4-(4-(4-fluoro-3-(trifluoromethyl) phenyl)-1-methyl-1H-imidazol-2-yl) piperidin-1-yl)-1H-pyrazolo [3,4-d] pyrimidine
Targets
S6K
Molecular Formula
C21H19F4N7
Melting Point
276-280ºC
Solubility
May be dissolved in DMSO (1 mg/ml); DMF (3 mg/ml, warm)
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