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Lck inhibitor 2

Cat No.
CEI-1391
Product Overview
Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. 27.The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively. Lck inhibitor 2 (Compound 9) inhibited 48 kinases with %control <1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control <10.Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM).
CAS No.
944795-06-6
Molecular Weight
335.36
Purity
0.98
Storage
Store at -20°C
Targets
Tyrosine kinases
IC50
13 nM(Lck)
Molecular Formula
C18H17N5O2
Chemical Name
3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzamide
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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