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Leptomycin B

Cat No.
CEI-0451
Description
A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.
Alias
LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B
Appearance
White to yellowish solid
Product Overview
An inhibitor of nuclear export
CAS No.
87081-35-4
Molecular Weight
472.54
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B
Targets
XPO1
Molecular Formula
C₃₃H₄₈O₆
Solubility
DMSO (>15 mg/ml) or H₂O (
Shipping Conditions
Gel pack
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