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Limonin

Cat No.
CEI-1398
Product Overview
Limonin is a chemically-induced carcinogenesis inhibitor and HIV-1 replication inhibitor. The human immunodeficiency virus (HIV) is a lentivirus that causes the acquired immunodeficiency syndrome (AIDS). When culturing the HIV-1 in human peripheral blood mononuclear cells (PBMC) and monocytes/macrophages (M/M), Limonin inhibit the HIV-1 replication in all cellular systems and inhibit HIV-1 replication with EC50 value of 60u μM in PBMC cells in a dose-dependent way. In human hepatoma HepG2 cells, limonin can induced apoptosis, which was evidenced by WB analysis of some apoptosis factors. In the female Syrian hamsters treated with DMBA, which can cause tumor, limonin showed a 60% reduction in tumor burden. It decreased 20% tumor number and 50% tumor mass. In male F344 rats treated with azoxymethane (AOM), 0.05% limonin in diet significantly reduced (65%-92% inhibition) the incidence of colonic adenocarcinoma. Thus, limonin has chemopreventive effects on chemically induced carcinogenesis.
CAS No.
1180-71-8
Molecular Weight
470.51
Storage
Store at -20°C
Synonyms
Limonoic acid 3,19:16,17 dilactone
Targets
HIV-1
Molecular Formula
C26H30O8
Chemical Name
12-(furan-3-yl)-6,6,8a,12a-tetramethyldecahydrooxireno[2,3-d]pyrano[4,3:3,3a]isobenzofuro[5,4-f]isochromene-3,8,10(1H,6H,8aH)-trione
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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