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Linsitinib (OSI-906)

Cat No.
CEI-0045
Description
Linsitinib (OSI-906) can inhibit IGF-1R and IR with IC50 of 35 nM and 75 nM.
CAS No.
867160-71-2
Molecular Weight
421.49
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
IGF-1R, IR
Molecular Formula
C26H23N5O
Chemical Name
(1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol
Solubility
DMSO 84 mg/mL Water
In vitro
Linsitinib (OSI-906) is a dual inhibitor of the IGF-1 receptor and insulin receptor. OSI-906 shows inhibition to hepatocellular carcinoma (HCC).
In vivo
A subset of HCC tumor cell lines was sensitive to OSI-906, where inhibition of the AKT pathway, but not the extracellular signal-regulated kinase (ERK) pathway, was associated with sensitivity.
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