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MC1568

Cat No.
CEI-1415
Description
MC1568 is a selective inhibitor of HDAC for maize HD1-A with IC50 of 100 nM. It is 34-fold more selective for HD1-A than HD1-B.
Product Overview
MC1568, a derivative of (Aryloxopropenyl)pyrrolyl hydroxyamide, is a novel, potent and specific inhibitor of class II histone deacetylase (HDAC), including two subclasses IIa (HDAC4, HDAC5, HDAC6, HDAC7 and HDAC9) and IIb (HDAC6 and HDAC 10), that exhibits strong inhibition against maize class II HDAC with 50% inhibition concentration IC50 value of 22 μM. MC1568 has been found to tissue-selectively inhibits HDAC and arrest myogenesis in cultured muscle cells through three possible mechanisms, including decreasing the expression of myocyte enhancer factor 2D, stabilizing the HDAC-HDAC3-MEF2D complex and inhibiting the acetylation of differentiation-induced MEF2D. Moreover, MC1568 is able to interfere with RAR-and PPARγ-mediated differentiation-inducing signaling pathways.
CAS No.
852475-26-4
Molecular Weight
314.31
Purity
0.985
Storage
Store at -20°C
Synonyms
MC 1568, MC-1568
Targets
HD1-A (Maize); HD1-B (Maize)
IC50
100 nM; 3400 nM
Molecular Formula
C17H15FN2O3
Chemical Name
(E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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