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MG-132

Cat No.
CEI-0620
Description
A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC50 = 3 µM). Prevents γ-secretase cleavage.
Alias
Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
Appearance
Orange solid
Product Overview
A proteasome inhibitor
CAS No.
133407-82-6
Molecular Weight
362.42
Purity
>95% by HPLC
Storage
-20 centigrade
Synonyms
Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
Targets
protease
Molecular Formula
C₂₆H₄₁N₃O₅
Solubility
DMSO
Shipping Conditions
RT
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