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Malantide, Protein Kinase Substrate

Cat No.
CSUB-0865
Description
Malantide, Protein Kinase Substrate is a synthetic tetradecapeptide derived from the phosphorylation site of the β-subunit of phosphorylase kinase. The compound is a highly specific substrate for PKA and has displayed PKI inhibition >90% substrate phosphorylation in various tissue extracts at a Km=15 μM for PKA and 223 μM for PKG. Malantide is also a substrate for PKC and catalyzes the phosphorylation of serine in other substrates, including troponin I. More recently the compound has been used in studies to directly detect the phosphorylated peptides by electrospray ionization mass spectrometry; shown as a realistic alternative to radioactivity and fluorescence detection in determining enzymatic activity.
Applications
A highly specific PKA substrate
Form
Solid
CAS No.
86555-35-3
Molecular Weight
1633.8
Storage
Store at -20° C
Synonyms
RTKRSGSVYEPLKI; RTLRSGSVYEPLKI; ARG-THR-LYS-ARG-SER-GLY-SER-VAL-TYR-GLU-PRO-LEU-LYS-ILE; H-ARG-THR-LYS-ARG-SER-GLY-SER-VAL-TYR-GLU-PRO-LEU-LYS-ILE-OH; HIGH-AFFINITY CAMP DEPENDENT PROTEIN KINASE SUBSTRATE; MALANTIDE; arg-thr-lys-arg-ser-gly-ser-val-tyr-*glu-pro-leu-; MALANTIDE SYNTHETIC >97% CAMP-DEPENDENT PROTEI
Molecular Formula
C72H124N22O21
MDL Number
MFCD00144718
Solubility
Soluble in water (1 mg/ml).
Refractive Index
1.361 (lit.)
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