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Manumycin A

Cat No.
CEI-0480
Description
An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC50 = 180 µM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.
Alias
NSC-622141; UFC 1C
Appearance
Off-white solid
Product Overview
A potent ras farnesyltransferase (FTase) inhibitor
CAS No.
52665-74-4
Molecular Weight
302.78
Purity
>90% by NMR
Storage
-20 centigrade
Synonyms
NSC-622141; UFC 1C
Targets
FNTB
Molecular Formula
C 31 H 38 N 2 O
Solubility
DMSO (100 mM)
Shipping Conditions
Gel pack
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CatalogCEI-0226
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CAS No.192185-72-1
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