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Matrix Metalloproteinase-2 from Human, Recombinant

Cat No.
NATE-0860
Description
Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processes such as angiogenesis, intimal hyperplasia, atherosclerosis and aneurysms. Recently, MMPs have been linked to neurodegenerative diseases such as Alzheimer's, and amyotrophic lateral sclerosis (ALS). Natural inhibitors of MMPs, tissue inhibitor of matrix metalloproteinases (TIMPs) exist and synthetic inhibitors have been developed which offer hope of new treatment options for these diseases.
Abbr
MMP-2, Recombinant (Human)
Alias
MMP-2
Source
CHO Cells
Species
Human
Product Overview
Recombinant, human pro-MMP-2 expressed in CHO cells. Can be used as a positive control for zymographic analysis, immunoblotting, and substrate cleavage assay. A portion (less than 10%) of the enzyme may be seen as a naturally-occurring dimer. Dimerization does not interfere with activation. May contain up to 10% TIMP proteins. During storage, a small portion (less than 10%) of the enzyme may also become activated.
Form
Liquid
Enzyme Commission Number
EC 3.4.24.24
CAS No.
146480-35-5
Molecular Weight
72 kDa
Purity
>90% by SDS-PAGE
Storage
< -70°C; Avoid freeze/thaw
Buffer
In 150 mM NaCl, 20 mM Tris-HCl, 5 mM CaCl₂, 0.05% BRIJ-35 Detergent, pH 7.4.
Synonyms
72 kDa Gelatinase; Matrix Metalloproteinase 2; Gelatinase A; EC 3.4.24.24; type IV collagenase; 3/4 collagenase; matrix metalloproteinase 5; 72 kDa gelatinase type A; collagenase IV; collagenase type IV; MMP 2; type IV collagen metalloproteinase; type IV collagenase/gelatinase
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CatalogEXWM-4305
ProductNamegelatinase A
EC No.EC 3.4.24.24
CAS No.146480-35-5
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