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NSC-207895 (XI-006)

Cat No.
CEI-0177
Description
NSC-207895 can inhibit MDMX with IC50 of 2.5 uM.
CAS No.
58131-57-0
Molecular Weight
279.25
Purity
>99%
Storage
2 years at -20 centigrade
Targets
MDMX
Molecular Formula
C11H13N5O4
Chemical Name
2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide
Solubility
DSMO 0.4 mg/mL Water
In vitro
NSC-207895 decreases both the MDMX mRNA and protein in MCF-7 cells. NSC-207895 induces expression of p53 as well as well-characterized p53-target gene, p21 and MDM2, in a dose-dependent manner in MCF-7 cells. NSC-207895 increases the mRNA levels of proapoptotic genes including PUMA, BAX, and PIG3 in a dose-dependent manner in MCF-7 cells. NSC-207895 acts as cytotoxic agent in the G/R-luc astrocytoma cell line with GI50 of 117 nM.
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