Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
NVP-ADW742
Cat No.
CEI-0008
Description
NVP-ADW742 can inhibit the insulin-like growth factor-I receptor with IC50 of around 100 nM to 200 nM
Alias
ADW742
CAS No.
475488-23-4
Molecular Weight
453.58
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
ADW742
Targets
Insulin-like growth factor-I receptor
Molecular Formula
C28H31N5O
Chemical Name
5-(3-(benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Solubility
DSMO 10 mg/mL Water
In vitro
NVP-ADW742 can inhibit the insulin-like growth factor-I receptor with IC50 of around 100 nM to 200 nM. NVP-ADW742 is a potent and selective IGF-IR kinase inhibitor that can efficiently inhibit the growth of cells that are highly dependent on IGF-I signaling. By inhibiting IGF-IR signaling, NVP-ADW742 can inhibit the growth of H526 cell line with IC50 of 0.4 mM. SCF-mediated Kit phosphorylation and Akt activation were inhibited with IC(50) values in the 1-5 mM.
In vivo
NVP-ADW742 monotherapy or its combination with cytotoxic chemotherapy had significant antitumor activity in an orthotopic xenograft MM model, providing in vivo proof of principle for therapeutic use of selective IGF-1R inhibitors in cancer.
Download
Download Datasheet