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Enzymes for Research, Diagnostic and Industrial Use

NVP-BSK805

Cat No.
CEI-0200
Description
NVP-BSK805
CAS No.
1092499-93-8(freebase)
Molecular Weight
563.47
Purity
>99%
Storage
2 years at -20 centigrade
Targets
JAK2
Molecular Formula
C27H28F2N6O.2HCl
Solubility
No
In vitro
NVP-BSK805 can potently suppress JAK2 with IC50 of 0.5 nM, and displays more than 20-fold selectivity towards JAK1, JAK3, and TYK2. NVP-BSK805 shows inhibition to causes JAK2V617F and JAK2 wild-type with IC50 of 0.5 nM. For cell lines, NVP-BSK805 inhibt JAK2V617F cells (Ba/F3) growth and induce cell apoptosis. NVP-BSK805 also can potently inhibit STAT5. By inducing activation of caspase cascades, NVP-BSK805 triggered cell death.
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