Description
Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of Rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
Abbr
CTSB, Native (Bovine)
Alias
CTSB; cathepsin B; APPS; CPSB
Form
Lyophilized powder containing sodium phosphate, sodium chloride and ~6% EDTA as stabilizer.
Activity
> 10 units/mg protein
Composition
Protein, > 30% biuret
Unit Definition
One unit will hydrolyze 1 μmole of Z-lysine p-nitrophenyl ester per min at pH 5.0 at 25°C.
Pathway
Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Assembly of collagen fibrils and other multimeric structures, organism-specific biosystem
Function
collagen binding; cysteine-type endopeptidase activity; proteoglycan binding
Synonyms
CTSB; cathepsin B; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II
