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Native Bovine Cathepsin C


Cat No.
NATE-0170
Description
Cathespin C is a dipeptidyl aminopeptidase that can sequentially remove dipeptides from a peptide chain with an unsubstituted N-terminus. The enzyme exhibits a preference for glycine and proline as N-terminal aminoacids. Substrates that have an N-terminal lysyl or arginyl residue, or a penultimate proryl residue are not targeted by this enzyme. The endopeptidase activity requires the presence of halide ions and sulfydryl activators.
Abbr
CTSC, Native (Bovine)
Alias
CTSC; DPP1; DPPI
Source
Bovine spleen
Species
Bovine
Applications
Cathepsin C has been used in a study that demonstrated the potential of a proteomics approach to identify novel proteins expressed by extravillous trophoblast and to uncover the mechanisms leading to disease states in pregnancy. Cathepsin C has also been used in a study to evaluate biodegradable thermogels. The enzyme from Creative Enzymes has been used in the activation of granzyme k (Gzmk) precursor from E. coli. Granzymes are granule-stored lymphocyte serine proteases that are implicated in T-and natural killer cell-mediated cytotoxic defense reactions.
Form
Lyophilized from a 1 M sodium chloride solution.
Enzyme Commission Number
EC 3.4.14.1
Activity
> 5 units/mg protein
CAS No.
9032-68-2
Composition
Protein, > 25% biuret
Unit Definition
One unit will produce 1 μmole of Gly-Phe-NHOH from Gly-Phe-NH2 and hydroxylamine per min at pH 6.8 at 37°C using DL-phenylalanine hydroxamic acid as the standard. In addition to its hydrolytic properties, cathepsin C catalyzes the polymerization of dipeptide amides.
Pathway
Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
Function
cysteine-type peptidase activity
Synonyms
CTSC; cathepsin C; 9032-68-2; EC 3.4.14.1; dipeptidyl aminopeptidase I; dipeptidyl transferase; dipeptidyl transferase; dipeptide arylamidase I; DAP I; dipeptidyl-peptidase I; DPP-I; CPPI; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS
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Product Name
EC No.
CAS No.
Source
Price
CatalogEXWM-4043
EC No.EC 3.4.14.1
CAS No.9032-68-2
Source
Related Protocols
CATHEPSIN C -Enzymatic Assay Protocol
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