Description
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic Human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Abbr
CTSD, Native (Bovine)
Form
Lyophilized powder containing Citrate buffer salts
Enzyme Commission Number
EC 3.4.23.5
Activity
> 2.0 units/mg protein
Unit Definition
One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37°C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path).
Pathway
Adaptive Immune System, organism-specific biosystem; Collagen degradation, organism-specific biosystem; Lysosome, organism-specific biosystem
Function
aspartic-type endopeptidase activity
Synonyms
CTSD; cathepsin D; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P
