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Native Bovine Protein Disulfide Isomerase

Cat No.
NATE-0533
Description
Protein Disulfide Isomerase (PDI) has the C-terminal ER retention sequence Lys-Asp-Glu-Leu. It has active, intracellular traffic to different cell compartments. PDI supports internalization of Chlamydia, cholera and diphtheria toxins in some hosts. PDI is required for Sindbis virus infection and aids in reducing HIV gp120 protein thiols. PDI facilitates formation of the correct disulfide bonds by promoting rapid reshuffling of disulfide pairings
Abbr
PDI, Native (Bovine)
Alias
PDI
Source
Bovine liver
Species
Bovine
Applications
Protein Disulfide Isomerase (PDI) is a ubiquitous, highly conserved redox chaperone enzyme from the thioredoxin superfamily. It is mainly l ocated in the ER, where it assists in protein-folding and thiol-disulfide exchanges. It is used to study functional role of PDI in parasite infection and the interaction between macrophage PDI and L. chagasi.
Product Overview
Protein Disulfide Isomerase (PDI) from bovine liver is a homodimer with a molecular weight of 107 kDa (gel filtration) and the molecular weight of the monomer has been reported at 57 kDA (SDS-PAGE). The enzyme is a glycoprotein with 12% total carbohydrate content, composed of 4.6% mannose, 2.5% galactose, 1.4% NANA, and 3.5% 2-acetamido-2-deoxyglucose.
Form
Lyophilized powder containing potassium phosphate buffer salts and stabilizer.
Enzyme Commission Number
EC 5.3.4.1
Activity
100-400 units/mg protein
CAS No.
37318-49-3
Purity
>95% (SDS-PAGE)
Unit Definition
One unit cause a change in A650 of 0.01 per min of a 1.0 mg/mL solution of insulin in the presence of dithiothreitol at pH 7.5 at 25°C.
Storage
−20°C
Synonyms
Protein disulfide isomerase; PDI; EC 5.3.4.1; 37318-49-3; S-S rearrangase
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CatalogNATE-0913
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SourceE. coli
CatalogEXWM-5507
EC No.EC 5.3.4.1
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Related Protocols
PROTEIN DISULFIDE ISOMERASE -Enzymatic Assay Protocol
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