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Native Human Calpain 1

Cat No.
NATE-0100
Description
Caplain 1 is a neutral calcium-dependent cysteine protease containing the EF-hand motif. The protease consists of two subunits; the larger subunit has four domains that are homologous with papain and calmodulin. The smaller subunit has one domain that shares homology with calmodulin. It is activated by micromolar levels of calcium and hence, it is also called as micro-calpain. Its activation leads to cellular protein degradation, neuronal cell degeneRation, and autoimmune demyelinating diseases such as multiple sclerosis.
Abbr
Calpain 1, Native (Human)
Alias
calpain 1, μ-calpain
Source
Human
Applications
Human calpain 1 has been used in a study to assess how the crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. Human calpain 1 has also been used in a study to investigate the synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors.
Product Overview
> 95% (SDS-PAGE)
Form
aqueous glycerol solution
Enzyme Commission Number
EC 3.4.22.52
CAS No.
78990-62-2
Storage
−70°C
Buffer
Solution in 20 mM Imidazole-HCl, 5 mM β-Mercaptoethanol, 1 mM EDTA, 1 mM EGTA, and 30% glycerol.
Pathway
Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Focal Adhesion, organism-specific biosystem; Integrin-mediated cell adhesion, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem
Function
calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; peptidase activity; protein binding
Synonyms
calpain 1, μ-calpain; calcium-activated neutral protease I; EC 3.4.22.52
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