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Native Human Cathepsin B


Cat No.
NATE-0168
Description
Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
Abbr
CTSB, Native (Human)
Alias
CTSB; APPS; CPSB
Source
Human liver
Species
Human
Form
buffered aqueous solution. Solution in 50 mM sodium acetate, pH 5.0, with 1 mM EDTA.
Enzyme Commission Number
EC 3.4.22.1
Activity
> 2 ,000 units/mg protein (E1%/280)
CAS No.
9047-22-7
Unit Definition
One unit will liberate 1 nanomole of 7-amino-4-methylcoumarin from Z-Arg-Arg 7-amido-4-methylcoumarin per min at pH 6.0 at 40°C.
Storage
−20°C
Pathway
Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Toll Receptor Cascades, organism-specific biosystem
Function
cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding
Synonyms
CTSB; cathepsin B; cathepsin B1; APPS; CPSB; EC 3.4.22.1; 9047-22-7; cathepsin II; CatB
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Related Protocols
CATHEPSIN B -Enzymatic Assay Protocol
CATHEPSIN B -Enzymatic Assay Protocol
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