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Native Human Cathepsin B
Cat No.
NATE-0168
Description
Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
Abbr
CTSB, Native (Human)
Alias
CTSB; APPS; CPSB
Source
Human liver
Species
Human
Form
Frozen in 50 mM Na Acetate, pH 5.0, with 1 mM EDTA
Enzyme Commission Number
EC 3.4.22.1
Activity
>= 200 units/mg protein
CAS No.
9047-22-7
Unit Definition
One unit is defined as the amount of enzyme that hydrolyzes one umole of Z-Arg-Arg-beta-naphthylamide per minute at 40°C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.
Storage
<= -70°C
Pathway
Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Toll Receptor Cascades, organism-specific biosystem
Function
cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding
Synonyms
CTSB; cathepsin B; cathepsin B1; APPS; CPSB; EC 3.4.22.1; 9047-22-7; cathepsin II; CatB
Download
Download Datasheet"Cathepsin B" Total Products Page
| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1706 | Cathepsin B from Human, recombinant | EC 3.4.22.1 | 9047-22-7 | E. coli | Inquiry |
| NATE-0167 | Native Bovine Cathepsin B | 9047-22-7 | Bovine spleen | Inquiry | |
| NATE-0169 | Native Human Cathepsin B | EC 3.4.22.1 | 9047-22-7 | Human placenta | Inquiry |
| EXWM-4192 | cathepsin B | EC 3.4.22.1 | 9047-22-7 | Inquiry |