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Native Human Factor α-XIIa

Cat No.
NATE-0882
Description
Human Factor α-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system. Human Factor XII and prekallikrein are thought to be involved in a reciprocal activation mechanism in which Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to XIIa. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade. ERL offers Factor α-XIIa which is activated by the autoactivation process with Dextran Sulfate and re-purified to remove the activator. The protein purity is determined by SDS-PAGE and activity is determined via clotting assay.
Abbr
Factor α-XIIa, Native (Human)
Alias
Factor α-XIIa
Source
Human
Species
Human
Activity
69.51 PEU/mg
Molecular Weight
80 kDa
Concentration
1.20 mg/ml
Storage
< -60°C
Buffer
4 mM sodium acetate-HCl/ 0.15 M NaCl/ pH 5.3
Synonyms
Human Factor Alpha-XIIa; Factor Alpha-XIIa; Factor α-XIIa
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