Description
Plasma kallikrein is an enzyme. This enzyme catalyses the following chemical reaction:Selective cleavage of some Arg-and Lys-bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin. This enzyme is formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
Abbr
Kallikrein, Native (Human)
Form
Type I, buffered aqueous solution, Solution in 20 mM Tris-HCl, pH 7.8 with 100 mM NaCl; Type II, lyophilized powder.
Enzyme Commission Number
EC 3.4.21.34
Activity
Type I, > 5 units/mg protein; Type II, 1-5 units/mg protein.
Unit Definition
One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.
Pathway
Blood Clotting Cascade, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem
Function
peptidase activity; serine-type endopeptidase activity
Synonyms
serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein; 9001-01-8; EC 3.4.21.34; plasma kallikrein
