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Native Human Proteinase 3


Cat No.
NATE-0640
Description
Proteinase 3 is a serine protease expressed in the granules of neutrophils and monocytes. It degrades elastin and is associated with myeloid leukemia and Wegener's granulomatosis.
Abbr
PRTN3, Native (Human)
Alias
PRTN3; ACPA; PR3
Source
Human leukocytes
Species
Human
Applications
Proteinase 3 has been shown to be important in the pathogenesis of human emphysema. It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.
Product Overview
Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts. > 95% (PAGE)
CAS No.
128028-50-2
Storage
−20°C
Pathway
C-MYB transcription factor network, organism-specific biosystem
Function
enzyme binding; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Synonyms
PRTN3; proteinase 3; ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3; myeloblastin; leukocyte proteinase 3; leukocyte proteinase 4; Wegener's granulomatosis autoantigen; proteinase PR-3; proteinase-3; PMNL proteinase; PR3 Ag
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