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Native Human Proteinase 3


Cat No.
NATE-0620
Description
Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis (formerly known as "Wegener's granulomatosis").
Abbr
PR3, Native (Human)
Alias
PRTN3; PR3
Source
Human Neutrophils
Species
Human
Form
Liquid
Enzyme Commission Number
EC 3.4.21.76
Activity
Typically > 0.1 U/mg protein
CAS No.
128028-50-2
Purity
> 96% (SDS-PAGE)
Unit Definition
One unit will hydrolize one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37°C and pH 7.5.
Storage
-20°C
Pathway
C-MYB transcription factor network, organism-specific biosystem
Function
enzyme binding; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Synonyms
PRTN3; proteinase 3; ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3; EC 3.4.21.76
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