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Native Human Urokinase

Cat No.
PHAM-263
Description
Urokinase is a serine protease (EC 3.4.21.73). Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.
Abbr
uPA (Human)
Alias
uPA; Urokinase
Source
Human kidney cells
Species
Human
Product Overview
Urokinase from human kidney cells
Form
lyophilized powder
Enzyme Commission Number
EC 3.4.21.73
CAS No.
9039-53-6
Warnings
Note: Higher activities are obtained when human plasminogen is used as substrate.
Pathway
ATF-2 transcription factor network, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem.
Function
protein binding; serine-type endopeptidase activity.
Synonyms
Urokinase; EC 3.4.21.73; urokinase-type plasminogen activator; uPA; U-plasminogen activator; Cellular plasminogen activator; Urinary plasminogen activator
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Related Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-1690
EC No.EC 3.4.21.73
CAS No.
SourceE. coli
CatalogPHAM-262
EC No.EC 3.4.21.73
CAS No.9039-53-6
SourceHuman urine
CatalogEXWM-4165
EC No.EC 3.4.21.73
CAS No.9039-53-6
Source
Related Protocols
urokinase -Enzymatic Assay Protocol
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