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Enzymes for Research, Diagnostic and Industrial Use

Necrosis Inhibitor, Necrox-2

Cat No.
CEI-0583
Description
A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 µM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400 µM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.
Appearance
Liquid
Product Overview
A necrosis inhibitor
Molecular Weight
654.7
Purity
>99% by HPLC
Storage
-20 centigrade
Targets
Necroptosis
Molecular Formula
C 25 H 32 N 4 O 4 S 2
Chemical Name
[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
Shipping Conditions
Gel pack
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