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Necrostatin 2

Cat No.
CEI-1442
Description
Necrostatin-2 (Nec-2) is a small molecule inhibitor ofRIPK2 kinase activity
Product Overview
Necrostatin 2 (Nec-2) is a novel and potent necroptosis inhibitor with EC50 of 50 nM. It is an analog of necrostatin 1 (nec-1). Necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented. Nec-2 is efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. There is limited record for Nec-2, but some reports are related with other necrostatins. Nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP1 in vitro.
CAS No.
852391-19-6
Molecular Weight
277.71
Purity
0.98
Storage
Store at -20°C
Synonyms
MTH-DL-Tryptophan, Necroptotic Inhibitor
Targets
RIPK2
Molecular Formula
C13H12ClN3O2
Chemical Name
(5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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