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Necrostatin-5
Cat No.
CEI-0585
Description
Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5
Alias
Nec-5
Appearance
Brown solid
Product Overview
A necroptosis inhibitor
CAS No.
337349-54-9
Molecular Weight
592.42
Purity
>98% by NMR
Storage
-20 centigrade
Synonyms
Nec-5
Targets
Necroptosis, Necrosis
Molecular Formula
C₁₉H₁₇N₃O₂S₂
Chemical Name
3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
Solubility
DMSO or Ethanol or water
Shipping Conditions
Gel pack
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