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Niclosamide
Cat No.
CEI-0672
Description
A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
Appearance
Yellow solid
Product Overview
A STAT3 signaling pathway inhibitor
CAS No.
50-65-7
Molecular Weight
294.41
Purity
>98% by TLC
Storage
-20 centigrade
Targets
STAT3
Molecular Formula
C₁₃H₈Cl₂N₂O₄
Chemical Name
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Solubility
DMSO ( 25 mg/ml)
Shipping Conditions
Gel pack
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