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Enzymes for Research, Diagnostic and Industrial Use

PAC-1

Cat No.
CEI-0186
Description
PAC-1
CAS No.
315183-21-2
Molecular Weight
392.49
Purity
>99%
Storage
2 years at -20 centigrade
Targets
procaspase-3
Molecular Formula
C23H28N4O2
Solubility
No
In vitro
PAC-1 activates procaspase-3 by chelating zinc ions, thus relieving the zinc-mediated inhibition and allowing procaspase-3 to auto-activate itself to caspase-3.PAC-1 can not induce cell death and caspase-3 activation in Apaf-1 knockout cells, suggesting that apoptosome formation is essential for caspase-3 activation by PAC-1-mediated cell death.
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